Figure 7
From: Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice
(A,B) Representative recordings showing EFS-evoked contractions (1, 2, 4 & 8 Hz, respectively) in wild-type (A) and TRPC4−/− detrusor strips (B), before and during the presence of the TRPC5 inhibitor, clemizole hydrochloride. (C) Summary bar charts showing mean amplitude of EFS-evoked contractions in the presence of clemizole hydrochloride (normalised to the control response at each frequency) in wild-type (open bars) and TRPC4−/− preparations (filled bars). Error bars represent SEM. *** denotes p < 0.001 and **** denotes p < 0.0001.
