Figure 5 | Scientific Reports

Figure 5

From: Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography

Figure 5

18F-FOL PET/CT imaging of rabbits. (A) Representative coronal views of in vivo PET/CT images of a rabbit (3.4 kg, tracer doses 40 MBq/kg) with 18F-FOL (88–90 min post-injection) and 18F-FDG (170–180 min post-injection). White arrows denote a segment with advanced atherosclerosis in the abdominal aorta, with an 18F-FOL maximum target-to-background ratio (TBR = maximum standardized uptake value (SUV) of aorta divided by mean SUV of blood as determined from the inferior vena cava, SUVmax, aorta/SUVmean, blood) of 6.0 and an 18F-FDG maximum TBR of 2.4. Enlarged coronal PET/CT images of the aorta are shown in the right panels. Blue arrows denote aorta with lower tracer uptake. PET images are displayed in the same color scale. (B) Representative 18F-FOL time-activity curves of plaque (white arrow in Figure A) and blood. (C) Distribution kinetics of 18F-FOL in the selected organs (mean ± SD, n = 4).

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