Table 1 Kinetic parameters (K m , V max and K i ) of creatinine uptake by MATE1 under various assay conditions.
From: Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1
Assay Conditions | K m (mM) | V max (nmol/min/mg) | K i (μM) |
|---|---|---|---|
Control | 4.31 ± 1.21 | 12.8 ± 1.4 | — |
Co-incubation with 2 μM crizotinib | 4.86 ± 1.96 | 6.89 ± 1.15 | 2.34 |
Control | 7.26 ± 1.29 | 27.7 ± 2.3 | — |
Pre-incubation with 1 μM crizotinib | 5.21 ± 1.14 | 8.66 ± 0.80 | 0.455 |
Control | 6.06 ± 1.00 | 29.4 ± 2.2 | — |
Pre/co-incubation with 0.5 μM crizotinib | 3.91 ± 0.87 | 11.9 ± 1.0 | 0.342 |
