Figure 1

Chromosomal imbalances in CC. Panel (A) hierarchical clustering indicating genomic DNA gains in red and losses in blue in the 22 somatic chromosomes and the X chromosome in 115 CC samples. Cervical cancer genomes show gains in 1p, 3q, 5p, 20, and 8q22.3 and 19q13.31 cytogenetic regions. Panel (B) and Panel (C) indicate the hierarchical clustering of the 8 and 19 chromosomes across the CC samples analyzed. In panel (A) white stripes in the acrocentric chromosomes 13, 14, 15, 21 and 22 corresponds to nucleolar organizer regions and stripes observed in chromosome 8 and 19 correspond to centromere on panel B and C.