Figure 3 | Scientific Reports

Figure 3

From: Immune interconnectivity of anatomically distant tumors as a potential mediator of systemic responses to local therapy

Figure 3

Changes in primary tumor volumes dependent on metastatic site recruitment index. Percentage change in volume of site A when a second tumor is seeded at site B. Sites are listed in order of decreasing recruitment index (RI). (A) Equal growth rates. If metastatic ‘Site B’ has a higher recruitment index than primary ‘Site A’ (RI B  > RI A ), growth of the primary tumor will increase (red shade). If the metastatic site has a lower recruitment index than the primary site (RI B  < RI A ), growth of the primary site will be decelerated (green shade). (B) Unequal growth rates. Even with only a small change in growth rate at one site, which tumors will experience growth or inhibition is no longer intuitively dependent on recruitment index or blood flow fraction.

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