Table 3 Efficacy of vaccines against clade 2.3.4.4 and clade 2.3.2.1 H5 highly pathogenic avian influenza viruses in chickens.
Vaccine group | Challenge virus | Mean HI titer 21 days after immunization (log2) | Virus shedding (EID50/ml) | Survival | |||
|---|---|---|---|---|---|---|---|
Day 3 p.c.a | Day 5 p.c. | ||||||
Oropharyngeal | cloacal | Oropharyngeal | cloacal | ||||
PR8-H5-NS1(73)H5 | FJ/5 | 8.6 ± 0.6 | 0/10 | 0/10 | 0/10 | 0/10 | 10/10 |
JS/7 | 5.4 ± 0.5 | 0/10 | 0/10 | 0/10 | 0/10 | 10/10 | |
PR8-2344H5 + PR8-2321H5 | FJ/5 | 8.8 ± 0.9 | 0/10 | 0/10 | 0/10 | 0/10 | 10/10 |
JS/7 | 8.4 ± 0.5 | 0/10 | 0/10 | 0/10 | 0/10 | 10/10 | |
PR8-2344H5 | FJ/5 | 8.9 ± 0.4 | 0/10 | 0/10 | 0/10 | 0/10 | 10/10 |
JS/7 | 0.8 ± 0.4 | 4/4 (4.2 ± 0.5) | 4/4 (4.4 ± 0.4) | NAb | NA | 0/10 | |
Control | FJ/5 | <1 | 4/4 (4.5 ± 0.6) | 4/4 (4.8 ± 0.5) | NA | NA | 0/10 |
JS/7 | <1 | 4/4 (4.1 ± 0.3) | 4/4 (4.5 ± 0.4) | NA | NA | 0/10 | |
