Figure 1
From: Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity
Cysteine has a widespread protective effect under hypoxia in ovarian cancer cells. Total cell death normalized by control for 16 and 24 h of assay for (A) ES2 cells and (B) OVCAR3 cells and total cell death in the first cycle (C1) and in the second cycle (C2) of treatments in (C) ES2, (D) OVCAR3, (E) OVCAR8, (F) A2780 parental cells and (G) A2780 cisR cells. N - Normoxia; NC - Normoxia supplemented with cysteine; H - Hypoxia; HC - Hypoxia supplemented with cysteine. Results are shown as mean ± SD. Cardinals represent statistical significance among hypoxia with and without cysteine supplementation within the same cycle of treatments. *p < 0.05, **p < 0.01, ***p < 0.001 (One-way ANOVA with post hoc Tukey tests).
