Figure 5
From: Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity
Cysteine and hypoxia (H) have a role on the response to carboplatin by ovarian cancer cells. Total cell death in the first (C1) and in the second (C2) cycles of treatments in the presence of Carboplatin for (A) ES2, (B) OVCAR3, (C) OVCAR8, (D) A2780 parental cells and (E) A2780 cisR cells. N – Normoxia; NC – Normoxia supplemented with cysteine; H – Hypoxia; HC – Hypoxia supplemented with cysteine. Results are shown as mean ± SD. Cardinals represent statistical significance among hypoxia with and without cysteine supplementation within the same cycle of treatments. *p < 0.05, **p < 0.01, ***p < 0.001 (One-way ANOVA with post hoc Tukey tests).
