Figure 7
From: Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity
All thiols but GSH are increased in patients with ovarian tumours- high GSH turnover. Total thiols quantification in serum from healthy individuals (donors) and in serum from patients with benign and malignant ovarian tumours for (A) HCys- Homocysteine, (B) Cys – cysteine, (C) GluCys – Glutamylcysteine, (D) GSH – Glutathione, (E) CysGly – Cysteinylglycine. Thiol concentration was normalized by protein concentration. Free total thiols quantification in serum from healthy individuals (donors) and in serum from patients with benign and malignant ovarian tumours for (F) HCys- Homocysteine, (G) Cys – cysteine, (H) GluCys – Glutamylcysteine, (I) GSH – Glutathione, (J) CysGly – Cysteinylglycine. Thiol concentration was normalized by protein concentration. Thiols concentration bound to proteins quantification in serum from healthy individuals (donors) and in serum from patients with benign and malignant ovarian tumours for (K) HcySSP – S-homocysteinylated proteins, (L) CysSSP – S-cysteinylated proteins, (M) GluCysSSPS – S-Glutamylcysteinylated proteins, (N) GSSP – S-glutathionylated proteins, (O) CysGlySSP – S-cysteinylglycinylated proteins. (P) RSSP – total S-thiolated proteins. Thiol concentration was normalized by protein concentration. Results are shown as median. The *represent the statistical significance among groups. *p < 0.05, **p < 0.01, ***p < 0.001 (independent samples Kruskal Wallis One-way ANOVA with multiple comparisons).
