Figure 5

Nintedanib inhibited the growth of human PCa PC3 tumor xenograft in nude mice. (a) Schematic plan detailing the Experimental 1 and 2 strategies employed for performing Nintedanib efficacy study against PC3 tumor xenografts in immunocompromised mice. Experiment 1 (animals treated from day 1 after cell injection till study end), and Experiment 2 (animals with established tumors treated from day 23 after cell injection till study end). (b–c) Tumor volume as a function of time (left panel) and at the study end (right panel) for Experiment 1and Experiment 2. Values are expressed as mean ± S.E.M. (n = 5–8 mice/group) (two-tailed t-test between treated groups and its respective control). ^*p < 0.05; ^**p < 0.01; ^***p < 0.001.