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Figure 2

From: The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats

Figure 2

Effect of chronic NP-1 administration on cumulative food intake and total body weight gain in Zucker rats. After a 15-day exposure to vehicle (VEH) or NP-1 (5 mg / Kg, daily, i.p.) the cumulative food intake and total body weight gain were evaluated in the lean rats (a,b) and obese rats (c,d). Values are presented as the means ± SEM (n = 6–9 rats per group). Cumulative food intake data were analysed using two-way ANOVA (treatment and time) and a Bonferroni post hoc test for multiple comparisons (a and c). Differences in total body weight gain between VEH and NP-1 treated groups were analysed through unpaired, two tailed t-tests with Welch’s corrections (b and d). *P < 0.05, **P < 0.01 and ***P < 0.001 denote significant differences compared with the vehicle-treated group (VEH).

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