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Figure 1

From: Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

Figure 1

PRMT5 inhibition attenuates growth and survival in cancer cell lines. (A) Chemical structure of GSK3326595 (left) and GSK3203591 (right). (B) gIC50 (nM) and (C) net cell growth/death (%) values following a 6-day treatment with GSK3203591 in a panel of cell lines representing various tumour types. Bars represent average values for individual cell lines. Top dose of assay 29 uM. Cell lines with average gIC50 < 1 uM and net cell growth/death <0% represent the most sensitive and cytotoxic cell lines, respectively.

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