Figure 5 | Scientific Reports

Figure 5

From: Conformation-dependent binding of a Tetrastatin peptide to αvβ3 integrin decreases melanoma progression through FAK/PI3K/Akt pathway inhibition

Figure 5

Characterization of the QS-13 residues crucial for αvβ3 integrin interaction. SK-MEL-28 melanoma cells were pre-incubated 30 min in the presence or absence of the RGDS peptide (1 to 20 µg/mL) or anti-αvβ3 blocking antibody (20 µg/mL) and adhesion was assessed. *p < 0.05, ***p < 0.01, ***p < 0.001 (a). SK-MEL-28 melanoma cells were incubated with different substituted peptides (b) tagged with biotin and with AF-488 streptavidin complex and analyzed by flow cytometry (c) and results are reported on a histogram (d).

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