Table 2 Pathway analysis of genes that were considerably inhibited or activated in Hmgb2−/− MSCs.
From: HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles
Inhibited pathways in Hmgb2−/− MSCs | p-value | Activated pathways in Hmgb2−/− MSCs | p-value |
|---|---|---|---|
Adipogenesis genes | 3.55E-06 | Focal Adhesion | 5.22E-09 |
White fat cell differentiation | 4.84E-04 | XPodNet-protein-protein interactions in the podocyte expanded by STRING | 5.52E-09 |
Retinol metabolism | 8.70E-04 | ||
Chemokine signaling pathway | 0.00179 | PodNet-protein protein interactions in the podocyte | 8.44E-09 |
Selenium micronutrient network | 0.00541 | Primary focal segmental glomerulosclerosis FSGS | 1.12E-07 |
PPAR signaling pathway | 0.00655 | Focal adhesion-PI3K-Akt-mTOR-signaling pathway | 3.05E-07 |
Oxidative stress | 0.00797 | Matrix metalloproteinases | 1.01E-06 |
Prostaglandin synthesis and regulation | 0.00971 | Integrin-mediated cell adhesion | 2.43E-05 |
Ovarian infertility genes | 0.00971 | IL-3 signaling pathway | 2.43E-05 |
Focal adhesions | 0.0116 | p53 signaling | 0.0013 |
Nuclear receptors | 0.0144 | TGF beta signaling pathway | 0.00338 |
Tryptophan metabolism | 0.0182 | Osteoblast | 0.00595 |
Selenium metabolism selenoproteins | 0.0215 | miRNAs involved in the DNA damage response | 0.00595 |
S1P pathways and spinal cord injury | 0.0285 | Complement and coagulation cascades | 0.006 |
Metapathway biotransformation | 0.029 | Alpha6-beta4 Integrin Signaling pathway | 0.00791 |
MAPK signaling pathway | 0.015 | ||
IL-7 signaling pathway | 0.0154 | ||
ErbB signaling pathway | 0.0173 | ||
Delta-Notch signaling pathway | 0.018 | ||
EGFR1 signaling pathway | 0.0185 | ||
PluriNetWork | 0.0228 | ||
Hypertrophy model | 0.0232 | ||
Regulation of actin cytoskeleton | 0.0346 | ||
Endochondral ossification | 0.0376 | ||
MAPK signaling pathway | 0.0408 | ||
Wnt signaling pathway NetPath | 0.0413 | ||
miRNA regulation of DNA damage response | 0.0423 | ||
Kit receptor signaling pathway | 0.0456 | ||
TFs regulate miRNAs related to cardiac hypertrophy | 0.0467 | ||
IL-5 signaling pathway | 0.0491 | ||
Inflammatory response pathway | 0.0492 |
