Figure 8
From: Intestinal permeability, digestive stability and oral bioavailability of dietary small RNAs

In vivo digestive stability of synthetic sRNAs in the small intestines of mice treated with anti-CD3, or aspirin. Mice were treated with anti-CD3 antibody (anti-CD3) or aspirin (Aspirin) for 5 days. In control group (Control), mice were intraperitoneally injected with hamster IgG isotype control. All mice were gavage fed a cocktail of synthetic sRNAs including 400 pmoles each MIR2911, SCR4, MIR168a and C7. The content of small intestines were analyzed for the surviving levels of the sRNAs 1 h after feeding. The concentration was calculated based on the assumption of 1 mL small intestine liquid volume. n = 5. Mean values within a column superscripted by the same letter are not significantly different at p ≤ 0.05.