Figure 1 | Scientific Reports

Figure 1

From: Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

Figure 1

The comparative structural analysis of four full-length structures of CarD_CdnL_TRCF family of proteins. CarD consists of two domains, NTD (marine) and CTD (orange), linked with a flexible linker (magenta). The NTDs of the available structures of the CarD_CdnL_TRCF family of proteins (a) Mtb CarD (light pink; PDB ID 4KBM) (b) Tth CarD (light green; PDB ID 4L5G) (c) Mxa CdnL (olive; PDB ID 2LWJ) were superposed upon domain-swapped dimeric Mtb CarD (PDB ID 4ILU). (d) The crystal structure of Tth CarD and the NMR structure of Mxa CdnL were superposed using monomeric Mtb CarD (magenta; PDB ID 4KBM) as a reference. Structural comparison reveals different conformational states of CarD observed in available structures (indicated by arrows), thus, suggesting flexible nature of the CarD_CdnL_TRCF family of proteins.

Back to article page