Figure 3 | Scientific Reports

Figure 3

From: Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

Figure 3

CarD exists as a homodimer in solution. SAXS-derived envelope of CarD was superposed using the available crystal structures of Mtb CarD using SUPCOMB. The crystal structure of the domain-swapped dimeric CarD fits well into the SAXS calculated envelope (NSD = 0.96, Fig. 3a) whereas the superposition of the monomeric CarD (NSD = 3.2, Fig. 3b) leaves multiple regions in the SAXS envelope unaccounted, suggesting a poor fit.

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