Figure 1

ΔdblGATA mice showed impaired glucose tolerance and a decreased expression of genes involved in energy metabolism. (a) RNA sequencing data obtained from the small intestine (SI) of 8–10-week-old wild-type (WT) and ΔdblGATA mice. The expression of 379 downregulated and 52 upregulated genes was observed in ΔdblGATA mice with a fragments per kilobase of exon per million fragments mapped value >0.1 in at least 1 out of 8 analysed samples. Red indicates a high expression and green indicates a low expression. (b) Real-time PCR analysis of Lpl in the SI. *p < 0.05 (Student’s t-test). (c) mRNA expression levels of adipogenic and adipokine genes in the perigonadal fat of 8–10-week-old male mice fed with a chow diet. *p < 0.05, **p < 0.01 (Student’s t-test for Lpl, Slc2a4, and Adipoq, Mann-Whitney test for Lep). (d) Body weight of 8–10-week-old male mice fed with a chow diet. (e) Glucose tolerance test of 8–10-week-old male mice fasted for 16 h (n = 10–12 mice/group). *p < 0.05, **p < 0.01 (Student’s t-test). Graphs show the mean ± standard error of the mean.