Figure 2
From: Eosinophils support adipocyte maturation and promote glucose tolerance in obesity
ΔdblGATA mice gained less weight and body fat and displayed impaired glucose tolerance on a high-fat diet (HFD). Wild-type (WT) and ΔdblGATA male mice were fed a HFD or chow diet for 12 weeks. (a) Weight change during feeding with a HFD or chow diet (n = 20–27 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001 (two-way ANOVA), WT + HFD vs. ΔdblGATA + HFD. #p < 0.05, ##p < 0.01, ###p < 0.001 (two-way ANOVA), ΔdblGATA + Chow vs. ΔdblGATA + HFD. (b) Body weight gain, perigonadal fat/body mass, and liver/body mass on a HFD or chow diet. **p < 0.01, ***p < 0.001 (one-way ANOVA). (c) Glucose tolerance test of the indicated mice fasted for 16 h (n = 13–15 mice/group). *p < 0.05, ***p < 0.001 (two-way ANOVA), WT + HFD vs. ΔdblGATA + HFD. (d) Western blots of insulin-stimulated phosphorylation of insulin receptor (IR) and protein kinase B (Akt) in the liver, perigonadal fat, and skeletal muscle. The data are representative of two independent experiments. Graphs show the mean ± standard error of the mean.
