Figure 3 | Scientific Reports

Figure 3

From: Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson’s disease

Figure 3

Post-treatment with PT302 reduces meth-mediated rotational behavior in hemiparkinsonian rats. Animals were treated with vehicle (n = 11) or high dose PT302 (equivalent to Exendin-4 2.0 mg/kg/ every 2 weeks, n = 8). (a) Time line of study demonstrating PT302/vehicle dosing (days 6, 20 and 34 relative to day 0 when lesioning was performed), meth-mediated rotation was examined on days 6, 20, 34 and 45 post-lesioning, a blood sample was taken on day 47 and animals were later euthanized. (b) Treatment with PT302 significantly reduced meth-induced rotation (p = 0.032, two way ANOVA).

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