Figure 4 | Scientific Reports

Figure 4

From: Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson’s disease

Figure 4

PT302 reduces 6-OHDA–mediated dopaminergic neurodegeneration in striatum. Typical striatal TH immunostaining and plasma Exendin-4 levels from (a) 3 rats (#866, 883, 886) receiving vehicle and (b) 3 rats (#881, 875, 882) receiving PT302. (c) Unilateral Injection of 6-OHDA significantly reduced striatal TH-IR in animals receiving vehicle (see left side). PT302 significantly mitigated TH-IR loss within the lesioned striatum (*p < 0.001, 2-Way ANOVA). L = lesioned side; non-L = non-lesioned side; veh = animals receiving vehicle; PT = PT302. Calibration = 250  μm.

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