Figure 5 | Scientific Reports

Figure 5

From: Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson’s disease

Figure 5

Post-treatment with PT302 protects against 6-OHDA–mediated dopaminergic neurodegeneration in the substantia nigra. Typical TH immunostaining from animals receiving vehicle (a), 3 rats (#866, #875, #886) or PT302 (b), 3 rats (#881, #875, #882). 6-OHDA lesioning caused a loss of TH-IR on the lesioned side in animals receiving vehicle (see left side). Treatment with PT302 ameliorated this TH-IR loss on the lesioned side. (c) TH-IR in substantia nigra was quantified every 360 um from bregma −4.2 mm to −6 mm for each animal. Post-treatment with PT302 significantly attenuated the loss of TH activity within the lesioned substantia nigra (*p < 0.001, 2-Way ANOVA. (L veh vs L PT302: *p < 0.001). Calibration = 250 μm.

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