Figure 1
From: Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis
Hepatic and PBMC transcriptome in distinct in Group A: SAH-IO. (A) Workflow and summary of the RNA-Seq performed in Group A: SAH-IO (n = 5) vs. Group B: SAH-NIO (n = 9) shown in left-panel and supervised clustering of hepatic transcriptome for genes with p < 0.05, Fold Change > 1.5in Group A: SAH-IO (n = 5) vs. Group B: SAH-NIO (n = 9) of discovery cohort shown in right panel. See also Supplementary Table-1. (B) Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) of hepatic transcriptome in Group A and Group B. See also supplementary table-3. (C) Selection of differentially regulated genes linked to iron-regulation, oxidative-stress and inflammation modules ([*] = p < 0.05) in the Hepatic transcriptome of Group A: SAH-IO vs. Group B: SAHNIO. (D) Supervised clustering of PBMC transcriptome for genes with p < 0.05, Fold Change >1.5 in Group A: SAH-IO (n = 5) vs. Group B: SAH-NIO (n = 9) of discovery cohort. See also supplementary table-5. (E) Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) of PBMC transcriptome in Group A: SAH-IO and Group B: SAHNIO. See also supplementary table-6. (F) Selection of differentially regulated genes linked to iron-regulation, oxidative-stress and inflammation modules ([*] = p < 0.05) in the PBMC transcriptome of Group A: SAH-IO vs. Group B: SAHNIO.
