Figure 4
From: Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis
Effect of Iron or Fenton can be reversed by iron chelation in healthy MDMs cells. (A) Relative expression of oxidative-stress, inflammation and iron-regulatory genes in MDMs treated with 50 uM-Fecl2 in presence or absence of 150 uM Kelfer. Genes significantly altered are labelled as ([*] = p < 0.05). (B) Relative expression of oxidative-stress, inflammation and iron-regulatory in MDMs treated with 50 uM-Fenton in presence or absence of 150 uM Kelfer ([*] = p < 0.05). (C) Relative expression of ADAM17, CD163 and associated genes in MDMs treated with 50 uM-Fecl2 in presence or absence of 150 uM Kelfer ([*] = p < 0.05). (D) Relative expression of ADAM17, CD163 and associated genes in MDMs treated with 50 uM-Fenton reagent in presence or absence of 150 uM Kelfer ([*] = p < 0.05). (E) Relative expression of apoptosis, ER stress and autophagy genes in MDMs treated with 50 uM-Fecl2 in presence or absence of 150 uM Kelfer ([*] = p < 0.05). (F) Relative expression of apoptosis, ER stress and autophagy genes in MDMs treated with 50 uM-Fenton reagent in presence or absence of 150 uM Kelfer ([*] = p < 0.05).
