Figure 3
From: Tissue and exosomal miRNA editing in Non-Small Cell Lung Cancer
Targetome analysis of A-to-I miRNA editing in miRNA seed regions. (a) Predicted targetome shifting for miRNAs edited in MSRs. (b) Diagram of anti-correlation analysis between WT/ED miRNAs and all expressed transcripts across all samples in both LUAD and LUSC cohorts, respectively. Significant anti-correlated transcripts were considered based on a negative Pearson’s product-moment correlation coefficient and P-value < 0.05. (c) Diagrams of targetome shifting for WT/ED miR-497-5p in LUSC samples in both normal and tumor conditions. The miRNA targetome results as the intersection of the set of predicted targets with the set of significantly anti-correlated transcripts.
