Table 3 Reversal potential together with parameters of activation, steady-state fast inactivation, and slow inactivation of wild-type and mutant NaV1.8 current expressed in HEK293-1B cells.

From: Loss-of-function mutations of SCN10A encoding NaV1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease

NaV1.8

Reversal potential

Activation (mV)

Steady-state fast inactivation

Slow inactivation

mV

n

V1/2

k

n

V1/2

k

n

V1/2

k

n

Wild-type

53.02 ± 1.61

23

−5.97 ± 1.93

10.80 ± 1.00

23

−49.14 ± 1.67

10.03 ± 1.07

23

−58.23 ± 2.86

10.32 ± 0.62

12

I1706V

49.39 ± 2.05

12

−13.23 ± 2.54*

7.51 ± 1.23*

12

−47.84 ± 2.02

10.03 ± 0.70

12

−58.60 ± 4.06

11.34 ± 1.22

7

N909K

49.84 ± 1.87

22

−9.43 ± 2.09

8.43 ± 0.45

22

−48.44 ± 1.42

10.25 ± 0.54

22

−56.87 ± 1.57

10.20 ± 0.85

16

K1809R

49.37 ± 1.63

24

−4.51 ± 2.14

11.41 ± 1.15

24

−50.72 ± 2.52

10.44 ± 0.53

22

−58.47 ± 2.74

12.24 ± 0.54*

11

N909K/K1809R

48.29 ± 1.83

24

−6.56 ± 2.37

10.77 ± 1.05

24

−47.24 ± 2.02

10.44 ± 0.48

23

−56.12 ± 2.36

11.75 ± 0.81

16

  1. Mean ± S.E.M.; V1/2, half maximal activation or inactivation voltage; k, slope factor; *p < 0.05 versus wild-type channels (unpaired t-test).
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