Figure 4

MT inhibited Ca²⁺ currents in DRG neurons. (A) MT attenuated the whole cell Ca²⁺ currents evoked by a step depolarization in DRG neurons and the effect could be washed out. (B) Average whole cell Ca²⁺ current density-voltage relationships curves of tested DRG neurons under 100 µM MT perfusion and washed out (n = 5). (C) The peak current density in MT perfusion and washout states. n = 5 in each group. *P ≤ 0.05, **P ≤ 0.01. Tukey’s post-hoc analysis. (D) Dose-response curve of MT for peak Ca²⁺ current, n = 5 in each point. (E) Activation curve of whole cell calcium channels before and after 100 µM MT perfusion, n = 5 in each group. (F) Inactivation curve of whole cell calcium channels before and after 100 µM MT perfusion, n = 5 in each group. Group data presented by mean ± SEM.