Figure 2

Glucose consumption (a) and lactate production (b) in the primary SCs of Wt and Tg-RGN rats cultured for 24 hours in the presence of high (17 mM) or low (8 mM) glucose concentrations, and GLUT1/3 inhibitor (in high glucose); intracellular concentration of glucose (c) and lactate (d) in the SCs of Wt and Tg-RGN rats cultured for 24 hours. Data are presented as mean ± S.E.M. (n ≥ 4 in each group). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 when compared with Wt group in the presence of high glucose; #P < 0.05, ##P < 0.01, and ###P < 0.001 when compared with Wt group in the presence of low glucose; $$$$P < 0.0001 when compared with the Tg-RGN group in the presence of high glucose.