Figure 4 | Scientific Reports

Figure 4

From: Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice

Figure 4

Systemic administration of furin prevents mice against osteoarthritis and regulates ALK1/ALK5 ratio. OA mice were treated with PBS, Furin (1 U/mice) or α1-PDX (14 µg/mice) and compared to sham-operated mice (n = 8 per group). (A) Representative sections of joints stained with Safranin-O (X400) and quantification of OA score for cartilage lesions. (B) Immunohistochemistry analysis for ALK1 and ALK5 expression (X200). (C) quantification of ALK1 and ALK5 (+) cells and ALK1/ALK5 ratio. (D) integrative scheme summarizing the effect of furin in chondrocytes. Data are mean ± SEM. *p < 0.05, **p < 0.01.

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