Figure 4 | Scientific Reports

Figure 4

From: Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system

Figure 4

Peak time during an SBF with PTZ and 4-AP administration. (A) Representative peak of an SBF at PTZ 1 mM administration. (a) Upper graph shows the histogram of spikes during an SBF obtained at 16 electrodes (orange circle; start time of SBFs, yellow circle; peak time of SBFs, blue circle; end time of SBFs). Under graph shows raster plots of spontaneous firing at 16 electrodes. (b) Dose dependency in neurons and co-culture samples (n ≧ 5, N.S. is not significant). Data were analyzed using one-way ANOVA followed by post hoc Dunnett test. (B) Representative peak of an SBF at 4-AP 60 µM administration. (a) The peak time of spikes during an SBF shifted to the beginning of the SBF. (b) Dose dependency in neurons and co-culture samples (n ≧ 5, **p < 0.01).

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