Figure 4 | Scientific Reports

Figure 4

From: Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

Figure 4

(A) MDA-MB-231 and MCF-7 breast cancer cells grown in 3D culture with vehicle (DMSO), jerantinine A (1) (5.36 µM or 1.22 µM‚ respectively) or colchicine (10 µM or 14.5 µM‚ respectively). Images from 96 h post agent exposure. Scale bar represents 200 µm. (B) Quantification of the area of the MDA-MB-231 3D colonies over a 96 h period post agent addition. Mean (±S.E.M.) values are given. (C) Quantification of the area of the MCF-7 3D colonies over a 96 h period post agent addition. Mean (±S.E.M.) values are given. Data were generated from ≥2 separate trials; n = 2 per trial; *p < 0.05, **p < 0.01, ****p < 0.0001.

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