Table 2 Comparisons of demographics, baseline neuropsychological test performances, and dementia conversion between the fast- and slow-decliners in patients with naMCI.

From: Prediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment

 

Fast-decliners (N = 22)

Slow-decliners (N = 99)

P-value

Age, years

74.0 (6.7)

70.4 (7.3)

0.037

Female, N (%)

18 (81.8)

69 (69.7)

0.253

Education, years

7.7 (5.8)

9.3 (5.2)

0.205

Total follow-up, years

3.5 (0.7)

3.9 (1.4)

0.049

APOE4 carrier, N (%)

3 (13.6)

11 (11.1)

0.634

Vascular risk factors

  Hypertension, N (%)

13 (59.1)

47 (47.5)

0.324

  Diabetes, N (%)

10 (45.5)

29 (29.3)

0.142

  Dyslipidemia, N (%)

4 (18.2)

28 (28.3)

0.331

  Cardiovascular disease, N (%)

2 (9.1)

19 (19.2)

0.258

  History of stroke, N (%)

1 (4.5)

10 (10.1)

0.412

GDepS

16.2 (8.1)

14.8 (8.5)

0.482

CDR-SB

2.1 (0.8)

1.1 (0.7)

<0.001

Conversion to dementia

19 (86.4)

10 (10.1)

<0.001

  AD

14 (73.7)

6 (60.0)

 

  DLB

2 (10.5)

3 (30.0)

 

  SVaD

2 (10.5)

1 (10.0)

 

  CBS

1 (5.3)

0 (0.0)

 
  1. Values are mean (SD) or number (%). Chi-square and Student’s t-tests were performed to compare demographic variables between the fast- and slow-decliners groups.
  2. Abbreviations: N = number; SD = standard deviation; APOE4 = apolipoprotein E ε4; GDepS = Geriatric Depression Scale, MMSE = Mini-Mental State Examination; CDR = Clinical Dementia Rating; CDR-SB = Clinical Dementia Rating Scale Sum of Boxes; K-BNT = Korean version of the Boston Naming Test; RCFT = Rey-Osterrieth Complex Figure Test; SVLT = Seoul Verbal Learning Test; COWAT = Controlled Oral Word Association Test; AD = Alzheimer’s disease; DLB = dementia with Lewy bodies; SVaD = subcortical vascular dementia; CBS = corticobasal syndrome.
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