Figure 1 | Scientific Reports

Figure 1

From: Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)

Figure 1

An overview of the study setting. The plasma samples for lipidomic analysis were obtained from the Finnish Type 1 Diabetes Prevention and Prediction Study (DIPP). The study cohort comprises the samples from three groups: children who progressed to T1D during the follow-up (PT1D), who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab), and control (CTR) subjects who remained islet autoantibody negative during the follow-up until the age of 15 years. The three study groups were matched by HLA-associated diabetes risk, gender and period of birth. For each child, longitudinal samples were obtained corresponding to the ages of 3, 6, 12, 18, 24, and 36 months. These age groups were selected with the objective of understanding the dynamics of the lipidome preceding the overt T1D. For each age cohort and study group, number of autoantibody positive children is marked.

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