Table 1 Demographic characteristics of study population.

From: Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)

 

PT1D

P1Ab

CTR

Gender (girls, boys)

(14, 26)

(14, 26)

(14, 26)

Age at time of diagnosis

(mean ± SD)

4.75 ± 2.94

NA

NA

Age at time of first seroconversion (mean ± SD)

1.34 ± 0.58

3.05 ± 2.50

NA

HLA risk haplotypes

High risk (DR3 - DQA1*05 - DQB1*02) /DRB1*0401/2/4/5 - DQA1*03 - DQB1*0302, girls, boys)

(4, 5)

(1, 3)

(2, 4)

Moderately increased risk*

(7, 14)

(9, 12)

(5, 9)

Slightly increased risk*

(2, 8)

(1, 8)

(1, 6)

Neutral*

 

(2, 1)

(3, 1)

Decreased risk and/or not possible to form haplotype*

 

(0, 2)

(3, 5)

  1. *Other than DR3 - DQA1*05 - DQB1*02)/DRB1*0401/2/4/5 - DQA1*03 - DQB1*0302. Abbreviations: children who progressed to T1D, who developed at least a single antibody but not develop T1D during the follow-up (P1Ab), and control (CTR) subjects who remained islet autoantibody negative during the follow-up, human leukocyte antigen (HLA). The major genetic determinants of T1D are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The carriers of the genotype DQB1*02/DQB1*03:02 or DQB1*03:02/x genotypes (here x≠ DQB1*02, DQB1*03:01, DQB1*06:02, or DQB1*06:03 alleles) were categorized into the T1D risk group and recruited for the DIPP follow up program.
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