Figure 2 | Scientific Reports

Figure 2

From: Exposure to Polycyclic Aromatic Hydrocarbons Leads to Non-monotonic Modulation of DNA and RNA (hydroxy)methylation in a Rat Model

Figure 2

Glutathione modulation in rat liver upon exposure to PAH mixture. Glutathione and glutathione disulfide ratio (GSH/GSSG) variation (A), glutathione (GSH) levels variation (B) and disulfide glutathione (GSSG) levels variation (C) over different doses (n = 8, excepting for dose 40 µg/kg b.w. were n = 7) are depicted. For better visualization, to obtain a more symmetric distribution of model residuals, a natural logarithm (ln) transformation was applied for GSH/GSSG. The means together with the standard error of the mean are shown as grey columns and bars, respectively. Based on the ANOVA statistical analysis, p- values (*<0.05; ** < 0.01; ***<0.001) have been calculated using a Bonferroni’s multiple comparisons test, as detailed in the section 2.3, in order to assess the statistical significance of the observed mean values as compared to the control group.

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