Figure 4 | Scientific Reports

Figure 4

From: Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

Figure 4

Analysis of inflammatory reaction after MKEY treatment. Human neutrophil recruitment to human platelets immobilized on collagen-coated glass slides under flow conditions (1 dyne/cm2), without or with TRAP-6 activation (50 µM) in presense of sMKEY (control) or MKEY (A) p = 0.001 (n = 3–6), monocyte/macrophage infiltration ((B) F4/80 staining), neutrophil infiltration ((C) specific esterase staining), and NET formation ((D) H3cit staining), in MKEY- and sMKEY-treated mice, one day after I/R; *p < 0.05 vs. control (n = 8); Scale bar 50 µm.

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