Figure 4 | Scientific Reports

Figure 4

From: Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells

Figure 4

The disrupted islet architecture and increase in α cell ratio in Robo mβKO islets is not due to defects in differentiation or maturation of β cells. (A) Immunofluorescent staining for Insulin (red) and Ucn3 (green) of control Ucn3-Cre;Robo1+/+,2+/+ and Ucn3-Cre;Robo1Δ/Δ,2flx/flx islets from 1.5–3 month old mice. (B) Immunofluorescent staining for Insulin (red) and MafA (green) of control Ucn3-Cre;Robo1+/+,2+/+ and Ucn3-Cre;Robo1Δ/Δ,2flx/flx islets from 1.5–3 months old mice. Disorganized islets do not show loss of β cell maturation.

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