Table 2 Summarized micro-CT results for the effects of NC-8 administration on ovariectomy-induced bone loss.

From: Isosteviol Derivative Inhibits Osteoclast Differentiation and Ameliorates Ovariectomy-Induced Osteoporosis

 

Sham

OVX-Vehicle

L

M

H

BMD

0.38 ± 0.03

0.17 ± 0.01a

0.19 ± 0.01

0.18 ± 0.01

0.21 ± 0.01b

BV/TV

58.91 ± 2.55

22.31 ± 1.32a

23.90 ± 1.42

22.47 ± 0.93

28.64 ± 1.56b

BS/TV

15.04 ± 0.36

7.13 ± 0.34a

7.71 ± 0.27

7.02 ± 0.28

8.49 ± 0.24b

Tb.N

4.52 ± 0.11

1.88 ± 0.10a

2.03 ± 0.10

1.83 ± 0.08

2.25 ± 0.06b

Tb.Sp

0.14 ± 0.01

0.66 ± 0.06a

0.59 ± 0.06

0.65 ± 0.05

0.50 ± 0.03b

Tb.Th

0.130 ± 0.004

0.115 ± 0.002a

0.118 ± 0.001

0.123 ± 0.002

0.124 ± 0.003

  1. BMD: bone mineral density (g/cm3); BV/TV: bone volume ratio (%); BS/TV: bone surface ratio (1/mm); Tb.N: trabecular bone number (1/mm); Tb.Sp: trabecular bone separation (mm); Tb.Th: trabecular bone thickness (mm); the values represents the means ± S.E.M. aP < 0.05 compared with the sham group. bP < 0.05 compared with the OVX-vehicle group.