Figure 1
From: Cytokine Regulation in Human CD4 T Cells by the Aryl Hydrocarbon Receptor and Gq-Coupled Receptors
Effect of AhR modulators on human CD4 T cell differentiation. Naïve human CD4 T cells were cultured with Th17-inducing cytokines (IL-1β, IL-6, IL-23, TGF-β) in the presence or absence of FICZ or CH223191 for 1–8 days. (A) Gene expression in cultures at daily intervals, normalized to the housekeeping gene HPRT. Data are combined from 3 experiments (n = 3) and shown as mean+/− SEM. (B) Cytokine levels in culture supernatants on days 6–8 measured by ELISA. Data are combined from 8 experiments (n = 7–8). LOD = limit of detection.
