Figure 3 | Scientific Reports

Figure 3

From: Biostatistics mining associated method identifies AKR1B10 enhancing hepatocellular carcinoma cell growth and degenerated by miR-383-5p

Figure 3

AKR1B10 expression profile in NCBI GEO datasets and HCC patients’ specimens (A) Comparison of AKR1B10 mRNA expression status respectively in GSE14520, GSE14323 and GSE6764 liver cancer datasets through t-test. AKR1B10 was significantly higher expressed in HCC tissues than that in the non-cancerous tissues (P = 3.50E-11 for GSE14323, P = 8.17E-7 for GSE14520 and P = 6.98E-9 for GSE6764). (B) Expression of AKR1B10 was high in 69.81% out of 53 HCC tumor specimens (37/53). On the contrary, most of the non-cancerous tissues presented a relative lower AKR1B10 expression. The expression of AKR1B10 in tumor tissues was frequently and significantly higher than adjacent non-cancerous tissues (P  < 0.05). (C) Representative graph immunohistochemistry analysis carried out on tissue microarray (200x).

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