Table 1 Classification results in % (6-fold cross-validation, LDA 100 runs, RF/SVM 20 runs) obtained distinguishing between AD and HC (top) and sMCI from pMCI (bottom).
AD patients (N = 322, PositivesP) vs. Healthy Controls (N = 404, NegativesN) (baseline analysis, †volumes corrected for age/gender/brain size) | ||||||||
|---|---|---|---|---|---|---|---|---|
structure | ACC (bACC) | SENS | SPEC | mean [rel. to HC] (SD) [mm3]P,† | mean (SD) [mm3]N,† | effect size (d) | p-value | sig. (corr.) |
RandomForest (all features) | 87 (86) | 83 | 90 | |||||
SVM (all features) | 90 (89) | 86 | 92 | |||||
(surrogate structures) | ||||||||
BrainTissue | 72 (71) | 63 | 78 | −17942.8 [\(\hat{=}\) −1.5%] (22718.7) | 0 (17403.6) | 0.900 | <0.00001 | ++ (++) |
CorticalGreyMatter | 68 (67) | 63 | 72 | −23635.9 [\(\hat{=}\) −4.6%] (28907.3) | 0 (24078.1) | 0.898 | <0.00001 | ++ (++) |
Ventricles | 72 (71) | 63 | 79 | 17757.3 [\(\hat{=}\) 46.2%] (22639.6) | 0 (17293.9) | 0.895 | <0.00001 | ++ (++) |
WhiteMatter | 57 (56) | 51 | 61 | 7242.2 [\(\hat{=}\) 1.7%] (29309.8) | 0 (28686.1) | 0.250 | 0.00086 | ++ (o) |
DeepGreyMatter | 52 (52) | 50 | 54 | −1549.1 [\(\hat{=}\) −0.9%] (13310.2) | 0 (11142.2) | 0.127 | 0.08834 | o (o) |
Brain | 54 (55) | 56 | 53 | 1199158.5 (132290.9) | 1212115.6 (118623.9) | 0.104 | 0.16526 | o (o) |
(selected individual structures) | ||||||||
Amygdala | 80 (80) | 76 | 84 | −452.0 [\(\hat{=}\) −20.0%] (332.0) | 0 (250.5) | 1.561 | <0.00001 | ++ (++) |
Hippocampus | 78 (78) | 75 | 80 | −1115.4 [\(\hat{=}\) −17.0%] (817.7) | 0 (660.7) | 1.519 | <0.00001 | ++ (++) |
EntA | 78 (78) | 76 | 80 | −801.3 [\(\hat{=}\) −19.0%] (583.3) | 0 (485.3) | 1.509 | <0.00001 | ++ (++) |
LeftHippocampus | 79 (78) | 76 | 81 | −588.1 [\(\hat{=}\) −18.4%] (423.1) | 0 (364.6) | 1.502 | <0.00001 | ++ (++) |
RightAmygdala | 80 (80) | 77 | 83 | −232.2 [\(\hat{=}\) −20.2%] (182.6) | 0 (139.4) | 1.452 | <0.00001 | ++ (++) |
LeftAmygdala | 78 (78) | 75 | 81 | −219.8 [\(\hat{=}\) −19.7%] (179.7) | 0 (135.5) | 1.403 | <0.00001 | ++ (++) |
RightHippocampus | 76 (75) | 71 | 79 | −527.3 [\(\hat{=}\) −15.7%] (488.0) | 0 (339.1) | 1.280 | <0.00001 | ++ (++) |
InfLatVent | 78 (77) | 65 | 89 | 1330.8 [\(\hat{=}\) 65.8%] (1367.4) | 0 (702.2) | 1.267 | <0.00001 | ++ (++) |
LeftInfLatVent | 77 (76) | 66 | 86 | 649.5 [\(\hat{=}\) 68.2%] (677.1) | 0 (360.6) | 1.237 | <0.00001 | ++ (++) |
ITG | 71 (71) | 69 | 73 | −2588.0 [\(\hat{=}\) −10.7%] (2506.9) | 0 (1954.5) | 1.168 | <0.00001 | ++ (++) |
progressive MCI (N = 177, PositivesP) vs. stable MCI (N = 166, NegativesN) (baseline analysis, †volumes corrected for age/gender/brain size) | ||||||||
structure | ACC (bACC) | SENS | SPEC | mean [rel. to HC] (SD) [mm3]P,† | mean [rel. to HC] (SD) [mm3]N,† | effect size (d) | p-value | sig. (corr.) |
RandomForest (all features) | 68 (68) | 72 | 64 | |||||
SVM (all features) | 67 (67) | 70 | 64 | |||||
(surrogate structures) | ||||||||
BrainTissue | 60 (60) | 51 | 69 | −12652.2 [\(\hat{=}\) −1.1%] (20144.6) | −4372.1 [\(\hat{=}\) −0.4%] (20741.3) | 0.405 | 0.00021 | ++ (+) |
Ventricles | 60 (60) | 51 | 70 | 12483.5 [\(\hat{=}\) 35.6%] (20045.3) | 4427.7 [\(\hat{=}\) 9.7%] (20676.8) | 0.396 | 0.00029 | ++ (+) |
CorticalGreyMatter | 56 (56) | 55 | 56 | −16743.9 [\(\hat{=}\) −3.2%] (27348.8) | −6929.4 [\(\hat{=}\) −1.3%] (26948.6) | 0.361 | 0.00091 | ++ (o) |
Brain | 51 (51) | 52 | 49 | 1222424.9 (131084.2) | 1238635.5 (118830.2) | 0.129 | 0.23200 | o (o) |
WhiteMatter | 48 (48) | 47 | 49 | 5966.3 [\(\hat{=}\) 1.3%] (27919.1) | 4607.3 [\(\hat{=}\) 1.0%] (26735.5) | 0.050 | 0.64592 | o (o) |
DeepGreyMatter | 47 (47) | 46 | 48 | −1874.6 [\(\hat{=}\) −1.0%] (11838.0) | −2050.0 [\(\hat{=}\) −1.1%] (11988.8) | 0.015 | 0.89167 | o (o) |
(selected individual structures) | ||||||||
Amygdala | 65 (65) | 63 | 68 | −387.4 [\(\hat{=}\) −16.5%] (308.7) | −149.4 [\(\hat{=}\) −6.4%] (352.2) | 0.720 | <0.00001 | ++ (++) |
LeftAmygdala | 62 (62) | 61 | 64 | −191.6 [\(\hat{=}\) −16.7%] (161.2) | −70.4 [\(\hat{=}\) −6.0%] (189.7) | 0.690 | <0.00001 | ++ (++) |
InfLatVent | 64 (64) | 54 | 74 | 1034.0 [\(\hat{=}\) 53.8%] (1097.9) | 358.6 [\(\hat{=}\) 17.4%] (903.1) | 0.670 | <0.00001 | ++ (++) |
LeftInfLatVent | 65 (65) | 56 | 75 | 480.0 [\(\hat{=}\) 53.9%] (538.2) | 156.3 [\(\hat{=}\) 15.8%] (451.1) | 0.650 | <0.00001 | ++ (++) |
RightAmygdala | 65 (65) | 63 | 67 | −195.8 [\(\hat{=}\) −16.4%] (176.7) | −79.0 [\(\hat{=}\) −6.7%] (184.1) | 0.648 | <0.00001 | ++ (++) |
EntA | 61 (61) | 61 | 60 | −678.3 [\(\hat{=}\) −15.6%] (565.7) | −294.0 [\(\hat{=}\) −6.7%] (622.8) | 0.647 | <0.00001 | ++ (++) |
RightInfLatVent | 64 (64) | 54 | 74 | 554.0 [\(\hat{=}\) 53.9%] (689.1) | 202.3 [\(\hat{=}\) 18.9%] (527.5) | 0.571 | <0.00001 | ++ (++) |
Hippocampus | 61 (61) | 63 | 60 | −1042.8 [\(\hat{=}\) −15.6%] (817.1) | −604.7 [\(\hat{=}\) −8.9%] (786.1) | 0.546 | <0.00001 | ++ (++) |
RightHippocampus | 63 (63) | 61 | 64 | −514.7 [\(\hat{=}\) −15.1%] (442.9) | −287.7 [\(\hat{=}\) −8.3%] (408.3) | 0.532 | <0.00001 | ++ (++) |
MTG | 60 (60) | 59 | 60 | −2305.3 [\(\hat{=}\) −7.9%] (2698.1) | −925.8 [\(\hat{=}\) −3.0%] (2708.9) | 0.510 | <0.00001 | ++ (++) |
