Table 4 Classification results in % (6-fold cross-validation, LDA 100 runs, RF/SVM 20 runs) for distinguishing between pMCI and sMCI based on volume change from baseline to m12 (top) or m24 (bottom). Individual structures are sorted by effect size. The 5 structures with largest effect size are listed explicitly. Significant group differences indicated by + (p < 0.05) and ++ (p < 0.001). Bonferroni-corrected significance in parentheses.
progressive MCI (N = 168, PositivesP) vs. stable MCI (N = 149, NegativesN) (longitudinal analysis, bl → m12) | ||||||||
|---|---|---|---|---|---|---|---|---|
structure | ACC (bACC) | SENS | SPEC | mean (SD) [%]P | mean (SD) [%]N | effect size (d) | p-value | sig. (corr.) |
RandomForest (all features) | 74 (73) | 77 | 70 | |||||
SVM (all features) | 74 (74) | 72 | 75 | |||||
(surrogate structures) | ||||||||
Ventricles | 68 (69) | 63 | 74 | 6.8 (4.3) | 3.4 (3.1) | 0.890 | <0.00001 | ++ (++) |
BrainTissue | 63 (63) | 64 | 63 | −1.2 (1.0) | −0.6 (0.8) | 0.652 | <0.00001 | ++ (++) |
CorticalGreyMatter | 64 (64) | 67 | 61 | −1.8 (1.7) | −0.8 (1.3) | 0.608 | <0.00001 | ++ (++) |
Brain | 58 (58) | 62 | 54 | −0.8 (0.8) | −0.4 (0.6) | 0.495 | 0.00002 | ++ (+) |
DeepGreyMatter | 64 (64) | 62 | 66 | −1.3 (1.2) | −0.7 (1.3) | 0.428 | 0.00017 | ++ (+) |
WhiteMatter | 63 (63) | 61 | 64 | −0.6 (0.9) | −0.4 (0.7) | 0.310 | 0.00615 | + (o) |
(selected individual structures) | ||||||||
Hippocampus | 67 (67) | 59 | 76 | −4.1 (3.2) | −1.7 (2.2) | 0.867 | <0.00001 | ++ (++) |
LateralVentricle | 67 (68) | 61 | 75 | 7.1 (4.6) | 3.6 (3.4) | 0.866 | <0.00001 | ++ (++) |
InfLatVent | 69 (69) | 63 | 75 | 6.7 (5.6) | 2.6 (3.8) | 0.845 | <0.00001 | ++ (++) |
LeftHippocampus | 67 (68) | 60 | 75 | −4.2 (3.3) | −1.7 (2.5) | 0.845 | <0.00001 | ++ (++) |
LeftLateralVentricle | 66 (67) | 60 | 73 | 7.2 (4.8) | 3.6 (3.5) | 0.836 | <0.00001 | ++ (++) |
progressive MCI (N = 140, Positives P ) vs. stable MCI (N = 107, Negatives N ) (longitudinal analysis, bl → m24) | ||||||||
RandomForest (all features) | 79 (78) | 82 | 74 | |||||
SVM (all features) | 76 (76) | 76 | 76 | |||||
(surrogate structures) | ||||||||
Ventricles | 71 (72) | 65 | 80 | 13.7 (7.4) | 7.1 (5.6) | 0.989 | <0.00001 | ++ (++) |
BrainTissue | 68 (69) | 62 | 76 | −2.3 (1.5) | −1.2 (1.0) | 0.845 | <0.00001 | ++ (++) |
DeepGreyMatter | 66 (67) | 64 | 69 | −2.1 (1.4) | −1.2 (1.0) | 0.714 | <0.00001 | ++ (++) |
CorticalGreyMatter | 65 (66) | 61 | 71 | −3.2 (2.5) | −1.7 (1.6) | 0.707 | <0.00001 | ++ (++) |
Brain | 63 (63) | 60 | 67 | −1.5 (1.1) | −0.8 (0.7) | 0.707 | <0.00001 | ++ (++) |
WhiteMatter | 64 (65) | 55 | 74 | −1.6 (1.3) | −0.8 (1.0) | 0.661 | <0.00001 | ++ (++) |
(selected individual structures) | ||||||||
FuG | 75 (76) | 69 | 83 | −3.1 (2.1) | −1.0 (1.4) | 1.141 | <0.00001 | ++ (++) |
Hippocampus | 73 (74) | 68 | 80 | −8.9 (5.1) | −3.7 (3.8) | 1.118 | <0.00001 | ++ (++) |
LeftHippocampus | 74 (74) | 72 | 77 | −9.3 (5.6) | −3.8 (4.2) | 1.083 | <0.00001 | ++ (++) |
EntA | 71 (72) | 66 | 77 | −7.4 (4.7) | −2.8 (3.6) | 1.070 | <0.00001 | ++ (++) |
InfLatVent | 70 (72) | 62 | 81 | 14.6 (8.9) | 6.2 (6.6) | 1.053 | <0.00001 | ++ (++) |
