Table 5 Overview over selected articles that use features from T1w MR images from the ADNI cohort. Table adapted from Falahati et al.7. CTH: cortical thickness, ENR: elastic net regression, HV: hippocampus, LLE: locally linear embedding, MBL: manifold-based learning, MIL: multiple instance learning, OPLS: orthogonal partial least square to latent structure, SR: spare regression, TBM: tensor-based morphometry.

From: Structural brain imaging in Alzheimer’s disease and mild cognitive impairment: biomarker analysis and shared morphometry database

Article

Dataset (field strength)

Features

Classifier

AD vs. HC

pMCI vs. sMCI

bACC

SENS

SPEC

NAD/NHC

bACC

SENS

SPEC

NpMCI/NsMCI

MALPEM

ADNI1/Go/2 (1.5/3 T)

ROI volumes

RF

86

83

90

322/404

68

72

64

177/166

MALPEM

ADNI1/Go/2 (1.5/3 T)

ROI volumes

SVM

89

86

92

322/404

67

70

64

177/166

Beheshti et al.82

ADNI1 (3T)

VBM+ROM and intensity features

SVM

93

89.1

96.8

92/94

75

76.9

73.2

71/65

Coupe et al.28

ADNI1 (1.5T)

ROI volumes and grading features

LDA

90.5

87

94

198/231

73.5

73

74

167/238

Chincarini et al.63

ADNI1 (1.5T)

intensity and textural features features from 9 ROIs

SVM

91.5

89

94

144/189

68.5

72

65

136/166

Guerr`ero et al.49

ADNI1 (1.5T)

learned ROIs via SR + MBL

SVM

85.5

86

85

106/175

71

75

67

116/114

Hu et al.83

ADNI1 (1.5T)

VBM and wavelet frame features

SVM

84.1

82.5

85.6

288/188

76.7

71.8

82.3

71/62

Liu et al.61

ADNI1 (1.5T)

ROI volumes, CTH

ENR + LLE

89.5

86

93

86/137

68

80

56

97/93

Tong et al.50

ADNI1 (1.5T)

local intensity patches

MIL

89

85

93

198/231

70

67

73

167/238

Wee et al.60

ADNI1 (1.5T)

correlative and ROI-based morphological features

SVM

92.4

90.4

94.3

198/200

74.0

63.5

84.4

89/111

Westman et al.62

ADNI1 (1.5T)

ROI volumes, CTH, curvature and folding features

OPLS

91.5

90

93

187/225

71.2

75.9

66.5

87/200

Wolz et al.34

ADNI1 (1.5T)

HV, CTH, TBM, MBL

LDA

89

93

85

198/231

68

67

69

167/238

Zu et al.84

ADNI1 (1.5T+PET)

ROI volumes

SVM

96

95.1

94.5

51/52

69.8

66.7

71.4

56/43