Table 1 Effect of telomere-length on melanoma-specific survival in different quantiles based on patients age at diagnosis.

From: Telomere length and survival in primary cutaneous melanoma patients

 

Univariate analysis*

Multivariate analysisƗ

Age groups

Telomere lengthǂ

Number

Dead

HR (95% CI)

Number

Dead

HR (95% CI)

<30 years

Long (T/S > 1.45)

41

0

ref

36

0

ref

Short (T/S ≤ 1.45)

48

4

3.91 (1.25–12.29)

43

4

3.82 (1.10–13.30)

30–40 years

Long (T/S > 1.30)

87

4

ref

73

4

ref

Short (T/S ≤ 1.30)

91

7

2.89 (1.20–6.91)

76

4

2.69 (1.03–7.03)

40–50 years

Long (T/S > 1.27)

95

6

ref

80

4

ref

Short (T/S ≤ 1.27)

99

9

2.13 (1.13–3.99)

82

5

1.90 (0.95–3.82)

50–60 years

Long (T/S > 1.10)

98

3

ref

86

2

ref

Short (T/S ≤ 1.10)

100

6

1.57 (1.00–2.47)

90

6

1.34 (0.81–2.23)

60–70 years

Long (T/S > 1.06)

95

10

ref

81

9

ref

Short (T/S ≤ 1.06)

98

16

1.16 (0.74–1.80)

89

15

0.95 (0.58–1.54)

70–80 years

Long (T/S > 1.02)

57

11

ref

45

9

ref

Short (T/S ≤ 1.02)

59

11

0.85 (0.47–1.56)

52

9

0.67 (0.35–1.28)

>80 years

Long (T/S > 0.90)

11

3

ref

9

3

ref

Short (T/S ≤ 0.90)

16

3

0.63 (0.27–1.46)

15

2

0.47 (0.19–1.16)

  1. *Main effects: Telomere length (P 0.02), Age (P < 0.0001); Interaction effect: telomere length*age (P0.05).
  2. ƗMain effects: Telomere length (P 0.03), Age (P 0.0001); Interaction effect: telomere length*age (P0.03).
  3. ǂTelomere length was dichotomized at median distribution of T/S ratios within corresponding age groups.
  4. Hazard ratio (HR) in multivariate model was adjusted for composite genetic risk score, gender, number of nevi, tumor location and tumor stage. HR values in bold indicate statistical significance (P < 0.05).
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