Figure 1 | Scientific Reports

Figure 1

From: Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium

Figure 1

Overview of analytical meta-analysis approach to understand the molecular mechanism of ZIKV Infection. The comparative analysis of transcriptome alterations due to ZIKV infection in different cell types were performed to identify a meta-signature of ZIKV infection (left top). Furthermore, to identify the core set of genes unique to ZIKV infection, we also performed a comparative analysis of the ZIKV transcriptome with transcriptomes of DENV, WNV, and JEV (right middle). The genes only in the ZIKV extended set and not the other transcriptome comprise the ZIKV-core signature (middle right). Both the ZIKV extended and core-signature genes were evaluated by regulatory pathway and gene ontology analysis (bottom).

Back to article page