Figure 3

Transcriptome landscape of alterations in human primary RPE cells after ZIKV infection. (A) Unsupervised analysis of transcriptome profile of uninfected (Ctr), and ZIKV virus-infected primary RPE cells at 48 and 96 hrs post-infection, (B) Venn diagram depicting comparison of ZIKV-altered genes at 48 h and 96 h post-infection, (C) Heatmap of top altered genes due to ZIKV infection, and (D) Pathway analysis on genes significantly upregulated (>2 fold) in ZIKV-infected RPE cells. In the heatmap, columns represent the samples and rows represent the genes. Gene expression is shown with pseudocolor scale (−3 to 3) with red denoting high expression level and green denoting low expression level of a gene.