Figure 6

Identification of ZIKV infection-associated “Core transcriptional signature.” (A) Comparative analysis of ZIKV meta-signatures and other flavivirus transcriptomes using Venn diagram, (B) Heatmap of ZIKV core genes (pink sidebar) and genes overlapping with other neurological disease-causing viruses signatures (red sidebar). The middle part of the heatmap contains genes shared with other viruses. Columns represent different datasets used for identifying the ZIKV core signature (Blue at bottom: Normal and Red: Infected), and rows represent genes. Gene expression is shown with pseudocolor scale (−2 to 2) with red denoting high expression and green denoting low expression of a gene. (C) Gene ontology processes with enriched genes from the ZIKV core set. (D) Disease set with significant over-representation of the ZIKV core signature (Raw P-value < 0.01).