Figure 7

Identification of key regulators associated with ZIKV infection based on interactive network analysis. (A) Co-expression based interactive network of ZIKV-associated core signature. The topological analysis of the interactive network identified top 10 key regulators critical for the stability of the ZIKV infection-related interactive network. Each node represents a gene, and edges represent co-expression-based interactions. (B) Co-expression-based interactive network shows the interaction of top 10 key regulators from the ZIKV core network (red color) with the extended set of genes associated with ZIKV infection. The side panel lists the top 10 key regulators associated with ZIKV infection. CHML and ALDH5A1 are two key molecules significantly associated with stability of the ZIKV network prepared from the ZIKV core and the extended sets of genes.