Table 1 Glimepiride metabolic kinetic parameters in human recombinase CYP2C9*1/*2/*3 (n = 3, mean ± SD).

From: CYP2C9 and OATP1B1 genetic polymorphisms affect the metabolism and transport of glimepiride and gliclazide

Protein

Km (μmol/L)

Vmax (nmol/min/mg)

CLint

CYP2C9*1

2.97 ± 1.18

21.58 ± 7.78

7.45 ± 3.02

CYP2C9*2

3.26 ± 1.76

15.69 ± 5.95*

4.11 ± 1.57*

CYP2C9*3

3.70 ± 2.34*

9.17 ± 3.03**

2.42 ± 1.48**

  1. **p < 0.01, *p < 0.05 (vs. CYP2C9*1a group).
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