Figure 6 | Scientific Reports

Figure 6

From: In-Vivo Nucleus Pulposus-Specific Regulation of Adult Murine Intervertebral Disc Degeneration via Wnt/Beta-Catenin Signaling

Figure 6

Suppression of b-Catenin in the nucleus pulposus reduced the compressive stiffness of lumbar IVDs but not of tail IVDs. (A) Experimental design/timeline of 4 mo old bCAT cKO mice and harvest after 1 mo. Red “X” indicates tissue harvest. Letters on the right of the “X’s” indicate the panels in the timeline. Safranin-O and mechanical properties (Compression, Tension, Neutral Zone) of (B,D) tail (n = 5–8) and (C,E) lumbar (n = 6–7) IVDs. Scale bar: (B,C) 100 µm. NP: nucleus pulposus; AF: annulus fibrosus. Data are presented as mean + SD. bCAT cKO vs. WT: *p < 0.05.

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